CD53

Across TCGA patient cohorts, CD53 protein abundance is significantly associated with the RNA expression of many other genes, with 16,613 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD53-associated genes across cancer lineages are TLR8, IL21R, and ARHGAP9. Each is linked with CD53 in more than 9 cancer types. Because this analysis shows association rather than direction, both CD53-to-partner and partner-to-CD53 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD53 versus TLR8 in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD53→partner) and Y-score (partner→CD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR8 →	+1.058	+0.709	<.001	<.001	3	10
GBM	IL21R →	+0.928	+0.494	<.001	<.001	3	10
OV	ARHGAP9 →	+1.179	+1.055	<.001	<.001	3	10
OV	FAM78A →	+0.737	+0.673	<.001	<.001	3	10
OV	DOCK2 →	+0.963	+0.639	<.001	<.001	3	10
OV	WAS →	+1.174	+1.038	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,613 associations by consensus.

CD53 vs TLR8 — OV

Explore this scatter interactively →