CD53

Across TCGA patient cohorts, CD53 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD53-associated genes across cancer lineages are Notch1, TSC1, and ATM. Each is linked with CD53 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD53-to-partner and partner-to-CD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CD53-low versus CD53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD53→partner) and Y-score (partner→CD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.147	+3.335	.007	.005	3	2
UCEC	TSC1 →	-0.136	-1.584	.042	.036	3	2
UCEC	ATM →	-0.482	-3.459	.006	.005	3	2
UCEC	14-3-3_beta →	-0.090	-3.432	.022	.005	3	1
UCEC	EGFR_pY1068 →	-0.236	-1.584	.016	.036	3	1
UCEC	FoxM1 →	+0.217	+1.584	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Notch1 by CD53 expression — UCEC

Explore this box plot interactively →