CD53

Across TCGA cell cohorts, CD53 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,343 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD53-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Purine ribonucleoside triphosphate metabolic process, and ATP metabolic process. Each is linked with CD53 in more than 9 cancer types. Because this analysis shows association rather than direction, both CD53-to-partner and partner-to-CD53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by CD53-low versus CD53-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD53→partner) and Y-score (partner→CD53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.138	+0.359	.001	.002	3	10
LARGE_INTESTINE	Purine ribonucleoside triphosphate metabolic process →	+0.059	+0.304	<.001	.001	3	9
LUNG_NSCLC_LUAD	ATP metabolic process →	+0.052	+0.246	<.001	<.001	3	9
OESOPHAGUS	Regulation of myoblast fusion →	+0.126	+0.367	<.001	.001	3	8
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.184	+0.378	<.001	.006	3	8
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.123	+0.353	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,343 associations by consensus.

Negative regulation of myoblast fusion by CD53 expression — OESOPHAGUS

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