CD52

Across TCGA cell cohorts, CD52 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,670 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CD52-associated GO terms across cancer lineages are B cell receptor signaling pathway, Negative regulation of syncytium formation by plasma membrane fusion, and Negative regulation of myoblast fusion. Each is linked with CD52 in more than 9 cancer types. Because this analysis shows association rather than direction, both CD52-to-partner and partner-to-CD52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by CD52-low versus CD52-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD52→partner) and Y-score (partner→CD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	B cell receptor signaling pathway →	-0.134	-0.713	.001	.001	3	10
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.086	+0.703	.008	.005	3	9
BREAST	Negative regulation of myoblast fusion →	+0.073	+0.563	.008	.004	2	8
BREAST	Proton motive force-driven ATP synthesis →	+0.088	+0.722	<.001	.004	3	7
PANCREAS	Striated muscle contraction →	+0.055	+0.722	.005	.006	2	7
BLOOD_Lymphoma	Myeloid leukocyte migration →	-0.089	-3.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,670 associations by consensus.

B cell receptor signaling pathway by CD52 expression — URINARY_TRACT

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