CD46

Across TCGA patient cohorts, CD46 mutation is significantly associated with the RNA expression of many other genes, with 1,353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD46-associated genes across cancer lineages are CHCHD1, SNORD114-7, and OR4D5. Each is linked with CD46 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD46-to-partner and partner-to-CD46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD1 grouped by CD46-low versus CD46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD46→partner) and Y-score (partner→CD46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD1 →	+0.393	+3.210	.005	.009	3	2
PRAD	SNORD114-7 →	+0.755	+6.921	<.001	<.001	3	2
LGG	OR4D5 →	+0.057	+5.846	<.001	.003	3	2
UCEC	RN7SL134P →	+0.131	+2.336	<.001	.006	3	2
PRAD	RN7SL702P →	+0.258	+5.109	<.001	.008	3	2
BLCA	COX6CP8 →	+0.073	+5.048	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,353 associations by consensus.

CHCHD1 by CD46 expression — UCEC

Explore this box plot interactively →