CD46

Across TCGA cell cohorts, CD46 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD46-associated genes across cancer lineages are GSK2276186C, LMP744, and GW-2580. Each is linked with CD46 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD46-to-partner and partner-to-CD46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2276186C grouped by CD46-low versus CD46-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD46→partner) and Y-score (partner→CD46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2276186C →	+0.504	+2.649	.029	.046	3	1
LARGE_INTESTINE	LMP744 →	+0.798	+2.649	.017	.046	3	1
LARGE_INTESTINE	GW-2580 →	+0.354	+2.786	.005	.037	3	1
LARGE_INTESTINE	Tivozanib →	+0.260	+2.786	.020	.037	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.471	+2.652	.047	.045	3	1
LARGE_INTESTINE	Olaparib →	+0.374	+2.672	.046	.039	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GSK2276186C by CD46 expression — LARGE_INTESTINE

Explore this box plot interactively →