CD40LG

Across TCGA pan-cancer cohorts, CD40LG Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CD40LG data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CD40LG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CD40LG expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC, STAD, and UCEC are the cancer types where CD40LG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.167	0.655	.038	12	view →
STAD	OS	Median	All	0.222	0.729	.004	12	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ESCA	DFS	Median	II,III,IV	0.149	0.522	.047	3	view →
SKCM	OS	Median	All	1.000	0.303	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CD40LG–KIRC (OS)

Open the KIRC breakdown →