CD40LG

Across TCGA patient cohorts, CD40LG mutation is significantly associated with the RNA expression of many other genes, with 1,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD40LG-associated genes across cancer lineages are EEF1E1-BLOC1S5, BUB1P1, and MIR449B. Each is linked with CD40LG in more than 1 cancer types. Because this analysis shows association rather than direction, both CD40LG-to-partner and partner-to-CD40LG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by CD40LG-low versus CD40LG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40LG→partner) and Y-score (partner→CD40LG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EEF1E1-BLOC1S5 →	+0.072	+4.351	<.001	.002	3	2
CESC	BUB1P1 →	+0.321	+5.010	<.001	.009	3	2
LUSC	MIR449B →	+0.277	+7.924	<.001	.008	3	2
LUAD	MIR150 →	+0.598	+4.426	<.001	.006	3	2
LUAD	M6PRP1 →	+0.031	+5.197	.002	.003	3	2
UCEC	MIR8071-1 →	+0.903	+1.662	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,870 associations by consensus.

EEF1E1-BLOC1S5 by CD40LG expression — SKCM

Explore this box plot interactively →