CD40LG

Across TCGA patient cohorts, CD40LG mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD40LG-associated genes across cancer lineages are Di-Ras3, EGFR_pY1068, and EGFR_pY1173. Each is linked with CD40LG in more than 1 cancer types. Because this analysis shows association rather than direction, both CD40LG-to-partner and partner-to-CD40LG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by CD40LG-low versus CD40LG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40LG→partner) and Y-score (partner→CD40LG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.197	-2.584	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.584	.007	.001	3	1
UCEC	EGFR_pY1173 →	+0.082	+2.479	.007	.010	3	1
UCEC	eIF4G →	+0.312	+3.169	.008	.018	3	1
UCEC	A-Raf_pS299 →	-0.157	-3.459	<.001	.005	3	1
UCEC	FoxM1 →	+0.215	+1.678	.030	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Di-Ras3 by CD40LG expression — UCEC

Explore this box plot interactively →