CD40LG

Across TCGA cell cohorts, CD40LG RNA expression is significantly associated with the go_rna of many other GO terms, with 219 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD40LG-associated GO terms across cancer lineages are Positive regulation of autophagy, CGAS/STING signaling pathway, and Regulation of chromatin organization. Each is linked with CD40LG in more than 1 cancer types. Because this analysis shows association rather than direction, both CD40LG-to-partner and partner-to-CD40LG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of autophagy grouped by CD40LG-low versus CD40LG-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40LG→partner) and Y-score (partner→CD40LG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of autophagy →	+0.021	+0.774	.002	.003	3	2
BLOOD_Leukemia	CGAS/STING signaling pathway →	+0.093	+1.132	<.001	.006	3	2
BLOOD_Leukemia	Regulation of chromatin organization →	+0.044	+0.641	.007	.006	3	2
BLOOD_Leukemia	Negative regulation of T cell mediated cytotoxicity →	+0.160	+1.027	.001	.007	3	2
BLOOD_Leukemia	Regulation of heterochromatin formation →	+0.054	+0.845	.001	.007	3	2
BLOOD_Leukemia	5S class rRNA transcription by RNA polymerase III →	+0.056	+0.721	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 219 associations by consensus.

Positive regulation of autophagy by CD40LG expression — BLOOD_Leukemia

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