CD40

Across TCGA patient cohorts, CD40 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD40-associated genes across cancer lineages are EGFR_pY1068, SETD2, and Di-Ras3. Each is linked with CD40 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD40-to-partner and partner-to-CD40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CD40-low versus CD40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40→partner) and Y-score (partner→CD40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.345	-3.169	.012	.020	3	1
UCEC	SETD2 →	-0.241	-2.999	.043	.035	3	1
UCEC	Di-Ras3 →	-0.228	-3.169	.005	.020	3	1
UCEC	14-3-3_beta →	-0.148	-3.156	.007	.020	1	1
UCEC	Cyclin-B1 →	+0.838	+3.169	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1068 by CD40 expression — UCEC

Explore this box plot interactively →