CD40

Across TCGA cell cohorts, CD40 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,055 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CD40-associated GO terms across cancer lineages are Positive regulation of interleukin-4-mediated signaling pathway, Positive regulation of protein kinase C signaling, and Response to 3,3',5-triiodo-L-thyronine. Each is linked with CD40 in more than 10 cancer types. Because this analysis shows association rather than direction, both CD40-to-partner and partner-to-CD40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of interleukin-4-mediated signaling pathway grouped by CD40-low versus CD40-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD40→partner) and Y-score (partner→CD40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of interleukin-4-mediated signaling pathway →	+0.817	+3.088	.002	<.001	3	11
LUNG_SCLC	Positive regulation of protein kinase C signaling →	+0.970	+2.997	.001	<.001	3	10
SOFT_TISSUE	Response to 3,3',5-triiodo-L-thyronine →	-0.199	-1.539	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of innate immune response →	+0.094	+1.802	.001	.004	3	9
PANCREAS	Antigen processing and presentation of endogenous peptide antigen →	+0.226	+2.473	<.001	.003	3	8
LUNG_SCLC	Carbohydrate derivative catabolic process →	+0.083	+2.624	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

Positive regulation of interleukin-4-mediated signaling pathway by CD40 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →