Across TCGA patient cohorts, CD3E protein abundance is significantly associated with the RNA expression of many other genes, with 12,947 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD3E-associated genes across cancer lineages are EBI3, CD2, and CD96. Each is linked with CD3E in more than 9 cancer types. Because this analysis shows association rather than direction, both CD3E-to-partner and partner-to-CD3E results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD3E→partner) and Y-score (partner→CD3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EBI3 →	+1.456	+0.825	<.001	<.001	3	10
GBM	CD2 →	+2.475	+1.490	<.001	<.001	3	10
GBM	CD96 →	+1.397	+1.490	<.001	<.001	3	10
COAD	TRAT1 →	+1.191	+0.515	.001	.001	3	10
UCEC	PYHIN1 →	+1.360	+0.973	<.001	<.001	3	10
UCEC	ICOS →	+1.286	+0.947	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,947 associations by consensus.

Exploration

CD3E survival (RNA) · tumor vs normal (RNA) · all CD3E data types