Across TCGA patient cohorts, CD3E mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD3E-associated genes across cancer lineages are OFD1P11Y, IGLL4P, and OR4X2. Each is linked with CD3E in more than 1 cancer types. Because this analysis shows association rather than direction, both CD3E-to-partner and partner-to-CD3E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD3E→partner) and Y-score (partner→CD3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OFD1P11Y →	+0.023	+7.471	<.001	.008	3	2
UCEC	IGLL4P →	+0.706	+2.671	<.001	.005	3	1
SKCM	OR4X2 →	+0.022	+4.302	<.001	.007	3	1
SKCM	HTR3D →	+0.038	+3.333	<.001	.004	3	1
SKCM	LINC00615 →	+0.046	+3.564	<.001	.005	3	1
SKCM	OR8B8 →	+0.021	+4.671	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Exploration

CD3E survival (RNA) · tumor vs normal (RNA) · all CD3E data types