Across TCGA cell cohorts, CD3E mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CD3E-associated genes across cancer lineages are CDX4, OR10K2, and PABPC1L2A. Each is linked with CD3E in more than 1 cancer types. Because this analysis shows association rather than direction, both CD3E-to-partner and partner-to-CD3E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD3E→partner) and Y-score (partner→CD3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.011	+4.217	<.001	.001	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
LARGE_INTESTINE	SCN11A →	+0.144	+3.772	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

CD3E survival (RNA) · tumor vs normal (RNA) · all CD3E data types