CD3D

Across TCGA pan-cancer cohorts, CD3D RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CD3D data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CD3D RNA is associated with better overall survival. In most high-consensus cancer types, elevated CD3D expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and BLCA are the cancer types where CD3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.458	0.262	<.001	109	view →
HNSC	DFS	Tertile	All	0.751	0.621	<.001	106	view →
BLCA	DFS	Tertile	All	0.444	0.225	.001	97	view →
UCEC	OS	Median	All	0.834	0.518	<.001	96	view →
UVM	OS	Median	All	0.427	0.759	<.001	95	view →
CESC	DFS	Median	All	0.832	0.646	<.001	82	view →
BRCA	DFS	Median	All	0.538	0.481	<.001	55	view →
LGG	OS	Median	All	0.729	0.884	<.001	47	view →
LUAD	OS	Tertile	III,IV	0.808	0.427	.001	42	view →
COAD	DFS	Median	III,IV	0.723	0.466	.007	27	view →
CHOL	DFS	Median	All	0.692	0.120	<.001	21	view →
GBM	DFS	Median	All	0.198	0.322	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CD3D–SKCM (OS)

Open the SKCM breakdown →