CD38

Across TCGA patient cohorts, CD38 mutation is significantly associated with the RNA expression of many other genes, with 2,947 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD38-associated genes across cancer lineages are POLR3KP2, KMT5AP1, and RASSF1-AS1. Each is linked with CD38 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD38-to-partner and partner-to-CD38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR3KP2 grouped by CD38-low versus CD38-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD38→partner) and Y-score (partner→CD38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	POLR3KP2 →	+0.713	+5.093	<.001	.008	3	3
UCEC	KMT5AP1 →	+0.211	+3.254	<.001	.008	3	2
UCEC	RASSF1-AS1 →	+0.408	+3.365	.006	.004	3	2
LUAD	LINC01757 →	+0.115	+4.399	<.001	.008	3	2
LUAD	LINC01162 →	+0.849	+3.659	<.001	.009	3	2
LUAD	LINC02578 →	+0.140	+4.502	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,947 associations by consensus.

POLR3KP2 by CD38 expression — LUSC

Explore this box plot interactively →