CD38

Across TCGA patient cohorts, CD38 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD38-associated genes across cancer lineages are C-Raf, JNK_pT183_Y185, and JNK2. Each is linked with CD38 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD38-to-partner and partner-to-CD38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CD38-low versus CD38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD38→partner) and Y-score (partner→CD38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.177	+2.807	.004	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-2.102	.044	.019	3	1
UCEC	JNK2 →	+0.261	+2.807	.002	.003	3	1
UCEC	Ku80 →	+0.256	+3.469	.013	.002	3	1
UCEC	Tuberin →	+0.389	+3.321	<.001	.009	3	1
UCEC	Caspase-8 →	-0.304	-3.906	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C-Raf by CD38 expression — UCEC

Explore this box plot interactively →