CD38

Across TCGA cell cohorts, CD38 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,793 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD38-associated GO terms across cancer lineages are Nucleocytoplasmic transport, Phosphatidylinositol biosynthetic process, and Negative regulation of endoplasmic reticulum unfolded protein response. Each is linked with CD38 in more than 6 cancer types. Because this analysis shows association rather than direction, both CD38-to-partner and partner-to-CD38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleocytoplasmic transport grouped by CD38-low versus CD38-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD38→partner) and Y-score (partner→CD38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nucleocytoplasmic transport →	+0.059	+0.211	.001	.005	3	7
BLOOD_Leukemia	Phosphatidylinositol biosynthetic process →	+0.051	+2.030	<.001	<.001	3	7
URINARY_TRACT	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.128	+0.155	<.001	<.001	3	6
URINARY_TRACT	Negative regulation of response to endoplasmic reticulum stress →	+0.132	+0.168	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.069	+0.490	.003	.009	2	7
BREAST	Positive regulation of cytoplasmic translation →	+0.134	+0.216	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,793 associations by consensus.

Nucleocytoplasmic transport by CD38 expression — BREAST

Explore this box plot interactively →