CD38

Across TCGA cell cohorts, CD38 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CD38-associated genes across cancer lineages are C10orf53, MROH9, and SPATA3. Each is linked with CD38 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD38-to-partner and partner-to-CD38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by CD38-low versus CD38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD38→partner) and Y-score (partner→CD38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.024	+5.217	<.001	<.001	3	1
LUNG_NSCLC_LUAD	MROH9 →	+0.303	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPATA3 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2V2 →	+0.038	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C10orf53 by CD38 expression — LARGE_INTESTINE

Explore this box plot interactively →