CD37

Across TCGA patient cohorts, CD37 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD37-associated genes across cancer lineages are eEF2, EGFR_pY1068, and GAPDH. Each is linked with CD37 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD37-to-partner and partner-to-CD37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CD37-low versus CD37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD37→partner) and Y-score (partner→CD37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.464	+2.321	.009	.035	3	1
UCEC	EGFR_pY1068 →	-0.252	-2.321	.045	.035	3	1
UCEC	GAPDH →	+0.572	+2.321	.034	.035	3	1
UCEC	Ku80 →	+0.363	+3.009	.002	.019	3	1
UCEC	mTOR_pS2448 →	-0.153	-2.321	.041	.035	3	1
UCEC	Notch1 →	+0.255	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by CD37 expression — UCEC

Explore this box plot interactively →