CD34

Across TCGA cell cohorts, CD34 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD34-associated genes across cancer lineages are AKR1D1, MMP27, and SPATA4. Each is linked with CD34 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD34-to-partner and partner-to-CD34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKR1D1 grouped by CD34-low versus CD34-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD34→partner) and Y-score (partner→CD34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKR1D1 →	+0.014	+3.450	.005	.004	3	1
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1
BLOOD_Leukemia	SPATA4 →	+0.082	+3.784	.002	.008	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.475	<.001	.006	3	1
BLOOD_Leukemia	SCGB1D1 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	WFDC12 →	+0.171	+4.289	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

AKR1D1 by CD34 expression — BLOOD_Leukemia

Explore this box plot interactively →