CD33

Across TCGA cell cohorts, CD33 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,107 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD33-associated GO terms across cancer lineages are NADH dehydrogenase complex assembly, Mitochondrial respiratory chain complex I assembly, and Regulation of skeletal muscle contraction. Each is linked with CD33 in more than 5 cancer types. Because this analysis shows association rather than direction, both CD33-to-partner and partner-to-CD33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NADH dehydrogenase complex assembly grouped by CD33-low versus CD33-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD33→partner) and Y-score (partner→CD33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NADH dehydrogenase complex assembly →	+0.052	+0.093	.002	<.001	3	6
PANCREAS	Mitochondrial respiratory chain complex I assembly →	+0.052	+0.093	.002	<.001	3	6
STOMACH	Regulation of skeletal muscle contraction →	-0.167	-1.262	.001	.003	3	5
BLOOD_Leukemia	Protein folding →	+0.046	+3.524	<.001	<.001	3	5
BLOOD_Leukemia	Cotranslational protein targeting to membrane →	+0.079	+2.435	<.001	<.001	3	5
BLOOD_Lymphoma	Noradrenergic neuron differentiation →	-0.978	-1.474	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,107 associations by consensus.

NADH dehydrogenase complex assembly by CD33 expression — PANCREAS

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