CD33

Across TCGA cell cohorts, CD33 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CD33-associated genes across cancer lineages are OR1L1, IFNA14, and OR10G4. Each is linked with CD33 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD33-to-partner and partner-to-CD33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by CD33-low versus CD33-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD33→partner) and Y-score (partner→CD33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L1 →	+0.021	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IFNA14 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.016	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L1 by CD33 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →