CD33

Across TCGA cell cohorts, CD33 mutation is significantly associated with the mutation status of many other genes, with 1,859 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD33-associated genes across cancer lineages are PRLR, EPG5, and COL1A2. Each is linked with CD33 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD33-to-partner and partner-to-CD33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRLR grouped by CD33-low versus CD33-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD33→partner) and Y-score (partner→CD33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRLR →	+5.339	+4.772	.004	.004	1	3
LUNG_NSCLC_LUAD	EPG5 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	COL1A2 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	B4GALNT4 →	+4.339	+4.339	.009	.009	1	3
LUNG_SCLC	PEX6 →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	ACTC1 →	+5.502	+5.502	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,859 associations by consensus.

PRLR by CD33 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →