CD2AP

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CD2AP mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD2AP-associated genes across cancer lineages are mTOR_pS2448, Akt_pT308, and ASNS. Each is linked with CD2AP in more than 1 cancer types. Because this analysis shows association rather than direction, both CD2AP-to-partner and partner-to-CD2AP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD2AP→partner) and Y-score (partner→CD2AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECmTOR_pS2448 →-0.133-1.886.007.01532
UCECAkt_pT308 →+0.420+1.321.046.02932
UCECASNS →+0.438+2.415<.001.00332
UCECATM →-0.584-2.201<.001<.00132
UCEC4E-BP1 →+0.421+3.999<.001<.00132
UCECC-Raf →+0.194+2.662<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration