Across TCGA cell cohorts, CD2AP mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD2AP-associated genes across cancer lineages are KRTAP16-1, KRTAP19-6, and GAGE12J. Each is linked with CD2AP in more than 1 cancer types. Because this analysis shows association rather than direction, both CD2AP-to-partner and partner-to-CD2AP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD2AP→partner) and Y-score (partner→CD2AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP16-1 →	+0.023	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUSC	KRTAP19-6 →	+0.140	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LARGE_INTESTINE	TAAR5 →	+0.011	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MDGA2 →	+0.110	+3.854	.006	.006	3	1
LARGE_INTESTINE	DEFB124 →	+0.082	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CD2AP survival (RNA) · tumor vs normal (RNA) · all CD2AP data types