CD28

Across TCGA pan-cancer cohorts, CD28 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CD28 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CD28 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CD28 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and LUAD are the cancer types where CD28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.161	0.579	.018	10	view →
UCEC	DFS	Median	II,III,IV	1.000	0.441	.025	8	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CD28–BRCA (OS)

Open the BRCA breakdown →