CD28

Across TCGA pan-cancer cohorts, CD28 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CD28 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CD28 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CD28 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD and HNSC are the cancer types where CD28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.885	0.438	.003	38	view →
HNSC	DFS	Median	III,IV	0.278	0.860	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CD28–LUAD (DFS)

Open the LUAD breakdown →