CD28

Across TCGA patient cohorts, CD28 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD28-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with CD28 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD28-to-partner and partner-to-CD28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CD28-low versus CD28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD28→partner) and Y-score (partner→CD28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.092	-2.295	.012	.033	3	1
UCEC	eEF2 →	+0.281	+1.874	.032	.049	3	1
UCEC	EGFR_pY1068 →	-0.210	-2.115	.023	.017	3	1
UCEC	eIF4E →	+0.210	+2.736	.006	<.001	3	1
UCEC	eIF4G →	+0.265	+3.321	.020	.009	3	1
UCEC	ERK2 →	+0.196	+2.459	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by CD28 expression — UCEC

Explore this box plot interactively →