CD276

Across TCGA patient cohorts, CD276 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD276-associated genes across cancer lineages are GAPDH, eIF4E, and Rictor_pT1135. Each is linked with CD276 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD276-to-partner and partner-to-CD276 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CD276-low versus CD276-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD276→partner) and Y-score (partner→CD276) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.481	+2.584	.026	.010	3	3
UCEC	eIF4E →	+0.267	+3.700	.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.103	-2.000	.012	.030	3	2
UCEC	TFRC →	+0.496	+3.169	.020	.018	3	2
UCEC	ATM →	-0.673	-3.446	<.001	.005	3	2
UCEC	Caspase-8 →	-0.342	-3.880	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GAPDH by CD276 expression — UCEC

Explore this box plot interactively →