CD276

Across TCGA cell cohorts, CD276 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD276-associated genes across cancer lineages are SHCBP1L, CCL11, and LY6H. Each is linked with CD276 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD276-to-partner and partner-to-CD276 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by CD276-low versus CD276-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD276→partner) and Y-score (partner→CD276) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SHCBP1L →	+0.086	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	CCL11 →	+0.018	+4.867	<.001	.009	3	1
SKIN	LY6H →	+0.185	+4.095	<.001	.009	3	1
LARGE_INTESTINE	GKN1 →	+0.051	+2.925	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	LRRC3C →	+0.269	+3.099	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SHCBP1L by CD276 expression — OESOPHAGUS

Explore this box plot interactively →