CD248

Across TCGA patient cohorts, CD248 mutation is significantly associated with the RNA expression of many other genes, with 2,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD248-associated genes across cancer lineages are MED28P6, MIR7702, and FAM177A1. Each is linked with CD248 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD248-to-partner and partner-to-CD248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED28P6 grouped by CD248-low versus CD248-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD248→partner) and Y-score (partner→CD248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MED28P6 →	+0.213	+5.149	.003	.007	3	3
UCEC	MIR7702 →	+0.214	+4.153	<.001	.005	3	3
UCEC	FAM177A1 →	+0.386	+3.354	.005	.005	3	2
UCEC	PELO →	+0.434	+2.233	.009	.006	3	2
UCEC	EME1 →	+0.719	+2.917	<.001	.001	3	2
UCEC	BUB1B →	+0.813	+3.708	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,153 associations by consensus.

MED28P6 by CD248 expression — GBM

Explore this box plot interactively →