CD248

Across TCGA patient cohorts, CD248 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD248-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Tuberin. Each is linked with CD248 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD248-to-partner and partner-to-CD248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CD248-low versus CD248-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD248→partner) and Y-score (partner→CD248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.784	+3.341	.004	.005	2	3
UCEC	MEK1 →	+0.366	+2.584	.032	.011	3	1
UCEC	Tuberin →	+0.281	+2.817	.025	.036	3	1
UCEC	Caspase-8 →	-0.239	-3.143	.041	.018	3	1
SKCM	Chk1 →	+0.212	+3.204	.042	.009	3	1
SKCM	c-Met_pY1235 →	-0.116	-2.987	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Caspase-7-cleavedD198 by CD248 expression — UCEC

Explore this box plot interactively →