CD244

Across TCGA patient cohorts, CD244 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD244-associated genes across cancer lineages are eIF4E, EGFR, and FOXO3a_pS318_S321. Each is linked with CD244 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD244-to-partner and partner-to-CD244 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CD244-low versus CD244-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD244→partner) and Y-score (partner→CD244) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.203	+2.807	.027	.003	3	2
UCEC	EGFR →	-0.188	-2.115	.007	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-2.449	.039	.019	3	1
UCEC	MEK1 →	+0.490	+3.584	.002	.002	3	1
UCEC	p62 Lck ligand →	+0.339	+2.179	.017	.034	3	1
UCEC	STAT3_pY705 →	-0.404	-1.874	<.001	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by CD244 expression — UCEC

Explore this box plot interactively →