CD22

Across TCGA cell cohorts, CD22 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,948 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CD22-associated GO terms across cancer lineages are Negative regulation of immunoglobulin production, Viral gene expression, and Formation of primary germ layer. Each is linked with CD22 in more than 13 cancer types. Because this analysis shows association rather than direction, both CD22-to-partner and partner-to-CD22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immunoglobulin production grouped by CD22-low versus CD22-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD22→partner) and Y-score (partner→CD22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of immunoglobulin production →	-0.212	-1.381	.001	.001	3	14
LUNG_NSCLC_LUAD	Viral gene expression →	+0.077	+1.122	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Formation of primary germ layer →	+0.064	+0.780	.005	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of ruffle assembly →	+0.167	+1.462	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of Rho protein signal transduction →	+0.112	+1.421	.001	.007	3	9
LUNG_NSCLC_LUSC	Hepatocyte growth factor receptor signaling pathway →	+0.210	+1.453	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,948 associations by consensus.

Negative regulation of immunoglobulin production by CD22 expression — LIVER

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