CD22

Across TCGA cell cohorts, CD22 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible CD22-associated genes across cancer lineages are CNTN3, BARHL2, and EVX2. Each is linked with CD22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD22-to-partner and partner-to-CD22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTN3 grouped by CD22-low versus CD22-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD22→partner) and Y-score (partner→CD22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CNTN3 →	+0.227	+3.044	.007	.008	3	1
STOMACH	BARHL2 →	+0.020	+3.044	<.001	.008	3	1
STOMACH	EVX2 →	+0.356	+3.044	.004	.008	3	1
STOMACH	FDCSP →	+1.379	+3.954	.002	.001	3	1
STOMACH	HNRNPCL3 →	+0.046	+3.662	<.001	.001	3	1
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CNTN3 by CD22 expression — STOMACH

Explore this box plot interactively →