CD200

Across TCGA pan-cancer cohorts, CD200 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CD200’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CD200 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CD200 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and BLCA are the cancer types where CD200 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD200 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.056	<.001	12	view →
LIHC	Male	II,III,IV	+1.485	<.001	9	view →
BLCA	All	All	−1.513	<.001	8	view →
KICH	Female	All	−1.440	<.001	7	view →
UCEC	All	All	−2.114	<.001	6	view →
BRCA	All	All	−1.148	<.001	6	view →
CHOL	All	All	+1.819	<.001	5	view →
HNSC	All	III,IV	+0.775	.031	5	view →
KIRP	All	All	+0.849	.001	3	view →
LUSC	Male	III,IV	−1.425	.003	2	view →
PRAD	All	All	−1.226	<.001	2	view →
STAD	All	II,III,IV	+0.614	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CD200–KIRC

Open the KIRC breakdown →