CD2

Across TCGA patient cohorts, CD2 mutation is significantly associated with the RNA expression of many other genes, with 1,828 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CD2-associated genes across cancer lineages are DPCD, STX3, and NUDCD2. Each is linked with CD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD2-to-partner and partner-to-CD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPCD grouped by CD2-low versus CD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD2→partner) and Y-score (partner→CD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DPCD →	+0.382	+2.584	.004	.001	3	2
SKCM	STX3 →	+0.736	+2.440	<.001	.001	3	2
SKCM	NUDCD2 →	+0.310	+2.299	.008	.004	3	2
SKCM	RRM2 →	+0.565	+1.591	.003	.003	3	2
SKCM	ZNF57 →	+0.331	+2.347	.004	.002	3	2
SKCM	KCMF1 →	+0.291	+2.188	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

DPCD by CD2 expression — SKCM

Explore this box plot interactively →