CD1E

Across TCGA patient cohorts, CD1E mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD1E-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and CD31. Each is linked with CD1E in more than 2 cancer types. Because this analysis shows association rather than direction, both CD1E-to-partner and partner-to-CD1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CD1E-low versus CD1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1E→partner) and Y-score (partner→CD1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.111	-2.446	.047	.018	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.354	-1.752	.036	.014	3	3
LUSC	CD31 →	-0.212	-2.990	.017	.036	3	2
LUAD	MIG-6 →	+0.190	+2.824	.027	.034	3	2
LUAD	p70-S6K →	+0.212	+2.000	.020	.031	3	2
UCEC	Cyclin-B1 →	+0.673	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR_pS2448 by CD1E expression — UCEC

Explore this box plot interactively →