CD1D

Across TCGA patient cohorts, CD1D mutation is significantly associated with the RNA expression of many other genes, with 2,708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD1D-associated genes across cancer lineages are ZNF816-ZNF321P, TOMM22, and SAMM50. Each is linked with CD1D in more than 2 cancer types. Because this analysis shows association rather than direction, both CD1D-to-partner and partner-to-CD1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF816-ZNF321P grouped by CD1D-low versus CD1D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1D→partner) and Y-score (partner→CD1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF816-ZNF321P →	+0.155	+3.668	<.001	.005	3	3
UCEC	TOMM22 →	+0.432	+3.839	.002	<.001	3	2
UCEC	SAMM50 →	+0.445	+2.606	.005	<.001	3	2
UCEC	NPRL2 →	+0.316	+3.756	.006	<.001	3	2
UCEC	SPR →	+0.631	+2.098	.001	.003	3	2
UCEC	DCLRE1B →	+0.566	+3.609	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,708 associations by consensus.

ZNF816-ZNF321P by CD1D expression — COAD

Explore this box plot interactively →