CD1D

Across TCGA patient cohorts, CD1D mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD1D-associated genes across cancer lineages are Caspase-7-cleavedD198, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with CD1D in more than 2 cancer types. Because this analysis shows association rather than direction, both CD1D-to-partner and partner-to-CD1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CD1D-low versus CD1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1D→partner) and Y-score (partner→CD1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.859	+2.019	<.001	.017	3	3
UCEC	MAPK_pT202_Y204 →	-0.417	-2.459	.031	.019	3	2
UCEC	mTOR_pS2448 →	-0.153	-3.439	.012	.005	3	2
UCEC	Caspase-8 →	-0.214	-2.432	.039	.018	3	2
UCEC	C-Raf →	+0.136	+2.321	.021	.034	3	2
UCEC	eIF4E →	+0.229	+3.584	.008	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by CD1D expression — UCEC

Explore this box plot interactively →