CD1C

Across TCGA patient cohorts, CD1C mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD1C-associated genes across cancer lineages are Caspase-7-cleavedD198, p27_pT198, and PCNA. Each is linked with CD1C in more than 2 cancer types. Because this analysis shows association rather than direction, both CD1C-to-partner and partner-to-CD1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CD1C-low versus CD1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1C→partner) and Y-score (partner→CD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.189	<.001	.001	3	3
UCEC	p27_pT198 →	+0.071	+1.392	.045	.019	3	2
UCEC	PCNA →	+0.182	+2.415	.010	.003	3	2
UCEC	Rab25 →	-0.310	-2.584	.004	.010	3	2
UCEC	Src →	-0.221	-2.781	.001	.003	3	2
UCEC	Cyclin-B1 →	+0.591	+2.700	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by CD1C expression — UCEC

Explore this box plot interactively →