CD1C

Across TCGA cell cohorts, CD1C mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CD1C-associated genes across cancer lineages are APOBEC1, KRT76, and C2orf80. Each is linked with CD1C in more than 1 cancer types. Because this analysis shows association rather than direction, both CD1C-to-partner and partner-to-CD1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOBEC1 grouped by CD1C-low versus CD1C-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1C→partner) and Y-score (partner→CD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APOBEC1 →	+0.816	+3.882	.001	.003	3	1
LUNG_NSCLC_LUAD	KRT76 →	+0.204	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	C2orf80 →	+0.077	+3.786	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR1J2 →	+0.102	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	SLC32A1 →	+0.098	+3.695	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

APOBEC1 by CD1C expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →