CD1B

Across TCGA patient cohorts, CD1B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD1B-associated genes across cancer lineages are PKC-delta_pS664, Rictor_pT1135, and XBP1. Each is linked with CD1B in more than 2 cancer types. Because this analysis shows association rather than direction, both CD1B-to-partner and partner-to-CD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by CD1B-low versus CD1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1B→partner) and Y-score (partner→CD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.111	-2.999	.040	.035	3	2
UCEC	Rictor_pT1135 →	-0.147	-2.700	.001	.006	3	2
UCEC	XBP1 →	-0.154	-2.986	.016	.035	3	2
UCEC	Caspase-8 →	-0.279	-3.432	.013	.005	3	2
UCEC	4E-BP1 →	+0.379	+3.351	.001	.005	2	3
SKCM	eIF4G →	+0.389	+2.807	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PKC-delta_pS664 by CD1B expression — UCEC

Explore this box plot interactively →