CD1B

Across TCGA cell cohorts, CD1B mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CD1B-associated genes across cancer lineages are FAM71C, SEMG1, and FNDC1. Each is linked with CD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CD1B-to-partner and partner-to-CD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71C grouped by CD1B-low versus CD1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD1B→partner) and Y-score (partner→CD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71C →	+0.012	+3.632	<.001	.003	3	1
LUNG_SCLC	SEMG1 →	+0.015	+3.169	<.001	.005	3	1
LUNG_SCLC	FNDC1 →	+0.607	+3.276	<.001	.007	3	1
LUNG_SCLC	SLC22A11 →	+0.042	+2.824	.009	.008	3	1
LUNG_SCLC	PRAMEF33 →	+0.279	+3.614	<.001	.001	3	1
BLOOD_Leukemia	GPR26 →	+0.139	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FAM71C by CD1B expression — LARGE_INTESTINE

Explore this box plot interactively →