CD19

Across TCGA patient cohorts, CD19 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD19-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with CD19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD19-to-partner and partner-to-CD19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CD19-low versus CD19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD19→partner) and Y-score (partner→CD19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.209	-1.906	.038	.016	3	2
UCEC	eIF4E →	+0.181	+1.906	.033	.016	3	2
UCEC	ERK2 →	+0.197	+2.807	.011	.003	3	2
COAD	PCNA →	+0.319	+3.178	.008	.010	3	2
UCEC	TIGAR →	+0.142	+2.441	.020	.001	3	2
UCEC	ATM →	-0.475	-2.415	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by CD19 expression — UCEC

Explore this box plot interactively →