CD180

Across TCGA patient cohorts, CD180 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD180-associated genes across cancer lineages are ATM, 14-3-3_beta, and PCNA. Each is linked with CD180 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD180-to-partner and partner-to-CD180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CD180-low versus CD180-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD180→partner) and Y-score (partner→CD180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.573	-2.991	.004	.036	3	3
UCEC	14-3-3_beta →	-0.107	-3.143	.008	.018	3	2
UCEC	PCNA →	+0.273	+3.087	.001	<.001	3	2
UCEC	Annexin-1 →	+0.608	+2.189	.004	.034	3	2
UCEC	Caspase-8 →	-0.260	-3.087	.010	<.001	3	2
UCEC	Di-Ras3 →	-0.229	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by CD180 expression — COAD

Explore this box plot interactively →