CD163

Across TCGA patient cohorts, CD163 mutation is significantly associated with the RNA expression of many other genes, with 4,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD163-associated genes across cancer lineages are KNSTRN, CDCA2, and ORC1. Each is linked with CD163 in more than 4 cancer types. Because this analysis shows association rather than direction, both CD163-to-partner and partner-to-CD163 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNSTRN grouped by CD163-low versus CD163-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD163→partner) and Y-score (partner→CD163) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KNSTRN →	+0.671	+1.847	<.001	.008	3	5
COAD	CDCA2 →	+0.645	+3.183	.004	.009	3	5
LUAD	ORC1 →	+0.668	+1.847	.002	.008	3	5
UCEC	CDKN3 →	+0.601	+1.551	<.001	<.001	3	4
LUAD	E2F1 →	+0.860	+3.718	<.001	<.001	3	4
UCEC	PARD6A →	+0.757	+1.722	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,323 associations by consensus.

KNSTRN by CD163 expression — LUAD

Explore this box plot interactively →