CD163

Across TCGA cell cohorts, CD163 mutation is significantly associated with the RNA expression of many other genes, with 191 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD163-associated genes across cancer lineages are ZNF764, CCL18, and ALG12. Each is linked with CD163 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD163-to-partner and partner-to-CD163 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF764 grouped by CD163-low versus CD163-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD163→partner) and Y-score (partner→CD163) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF764 →	+0.558	+3.212	.003	.006	3	2
LUNG_SCLC	CCL18 →	+0.038	+3.256	.005	.005	3	1
SKIN	ALG12 →	+0.688	+3.212	.005	.006	3	1
SKIN	FNTB →	+1.364	+3.299	<.001	.004	3	1
BLOOD_Lymphoma	SPRR2B →	+0.035	+5.643	<.001	.002	3	1
LARGE_INTESTINE	YWHAE →	+0.660	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

ZNF764 by CD163 expression — SKIN

Explore this box plot interactively →